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Acupuncture for pediatric pain: The trend of evidence-based research

Lin et al. · Journal of Traditional and Complementary Medicine · 2020

📊Systematic Review👥n=22 trials includedModerate evidence

Evidence Level

MODERATE
65/ 100
Quality
3/5
Sample
3/5
Replication
4/5
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OBJECTIVE

To evaluate scientific evidence for acupuncture in pediatric pain between 2008-2017

👥

WHO

Children and adolescents up to 18 years with different types of pain

⏱️

DURATION

Analysis of 10 years of research (2008-2017)

📍

POINTS

LI-4, ST-36, HT-7, EX-HN3, BL-60, KI-3 among others depending on condition

🔬 Study Design

1458participants
randomization

Procedural pain

n=802

55% of studies - surgeries and procedures

Infant colic

n=335

23% of studies - acupuncture at LI-4

Adolescent pelvic pain

n=262

18% of studies - dysmenorrhea and endometriosis

Headache

n=49

5% of studies - laser acupuncture

⏱️ Duration: Analysis period: 2008-2017

📊 Results in numbers

0%

Study success rate

18 of 22

Studies with positive results

0%

Significant pain reduction

0%

Most-used technique

Percentage highlights

82%
Study success rate
55%
Significant pain reduction
50%
Most-used technique

📊 Outcome Comparison

Efficacy by condition

Procedural pain
85
Adolescent pelvic pain
90
Headache
80
Infant colic
65
💬 What does this mean for you?

This broad analysis of 22 studies showed that acupuncture can be a safe and effective option for different types of pain in children. The best results were found for surgery-related pain, infant colic, adolescent menstrual pain, and headaches, with 82% of studies showing positive benefits.

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Article summary

Plain-language narrative summary

Pain in children and adolescents is a constant concern for parents and healthcare professionals. For a long time, it was believed that children felt less pain than adults or did not remember it, but today we know this is not true. Finding safe and effective ways to treat pediatric pain remains an important challenge, especially considering that many medications can have significant side effects in children. Acupuncture, an ancient practice of Traditional Chinese Medicine, has gained increasing recognition in the Western world as a complementary therapeutic option.

In adults, there is already robust evidence of its efficacy for various painful conditions, including postoperative pain, dental pain, and chemotherapy-related nausea. The growing interest in integrative therapies has led many professionals to explore the potential of acupuncture also in the care of children and adolescents, representing a promising alternative or complement to conventional treatments.

This study's main objective was to evaluate the current state of scientific research on the use of acupuncture for pain management in pediatric patients, specifically analyzing the randomized controlled clinical trials published between 2008 and 2017. The researchers conducted a systematic review of the literature, searching important medical databases such as PubMed, Cochrane Library, EMBASE, and others. They used specific keywords related to pediatrics, pain, and acupuncture to identify relevant studies. To ensure analysis quality, they established rigorous inclusion criteria: only prospective, randomized studies, with full-text access, related to pain treatment, that used valid and reliable assessment measures, with follow-up of participants over time.

Retrospective studies, research with objectives other than pain treatment, publications in languages other than English, and works available only as abstracts were excluded. From the initial total of 598 records found, after rigorous selection and analysis, 22 studies remained that met all established criteria, representing the most solid evidence available on the topic.

The results revealed an encouraging though still limited panorama. Approximately 82% of the analyzed studies (18 of 22) demonstrated positive results for the use of acupuncture in the treatment of pediatric pain. The most studied conditions were medical procedure-related pain (55% of studies), infant colic (23%), adolescent pelvic pain (18%), and headache (5%). In the context of medical procedures, acupuncture proved effective in reducing pain during and after various procedures, including heel puncture in newborns, tonsil surgeries, dental procedures, ear tube placement, and renal biopsies.

The studies used different techniques, from traditional filiform needles (50% of cases) to acupressure (pressure at specific points without needles), auricular acupuncture (on the ear), laser acupuncture, and electrical point stimulation. For infant colic, results were mixed: some studies showed significant reduction in crying time and pain intensity when specific points such as LI-4 (Hegu) were used, while others found no statistically significant benefits. In the treatment of adolescent pelvic pain, particularly related to menstruation and endometriosis, acupuncture and acupressure demonstrated promising efficacy.

The clinical implications of these findings are significant for both patients and healthcare professionals. For families, these results suggest that acupuncture can represent a safe and effective option for pain treatment in children, potentially reducing the need for analgesic medications and their possible side effects. The technique proved particularly valuable in situations where pain control is challenging, such as necessary but painful medical procedures. For healthcare professionals, the study offers evidence that may guide the integration of acupuncture into pediatric clinical practice.

The high rate of positive results (82%) suggests that, when applied appropriately and by qualified professionals, acupuncture can be a valuable tool in the therapeutic arsenal. Furthermore, the studies consistently demonstrated the safety of the procedure in children, with rare reports of significant adverse effects. For hospitals and clinics, these data may justify investments in integrative medicine programs aimed at the pediatric population.

However, the study also reveals important limitations that must be considered. First, the total number of high-quality clinical trials is still relatively small (only 22 studies in a decade), indicating that research in this area is still in its early stages. The heterogeneity of the studies, with different acupuncture techniques, points used, treatment duration, and outcome measures, made it impossible to perform combined statistical analyses of the data, limiting the strength of the conclusions. Furthermore, the studies focused on a restricted number of conditions, leaving many other causes of pediatric pain without adequate scientific evidence.

The four studies that found no benefit from acupuncture (two on heel puncture and two on infant colic) suggest that efficacy may depend significantly on the specific technique used, point selection, and population studied. The researchers emphasize that more randomized controlled clinical trials are urgently needed to establish standardized protocols and identify which children may benefit most from this therapeutic approach. Despite these limitations, the growing interest in integrative therapies and the promising results observed suggest an optimistic future for the integration of acupuncture into pediatric care, provided it is accompanied by rigorous research and responsible clinical practice.

Strengths

  • 1Comprehensive analysis of 10 years of research
  • 2High rate of studies with positive results (82%)
  • 3Diversity of pediatric conditions evaluated
  • 4Good representativeness with 22 clinical trials
  • 5Evidence of safety in pediatric populations
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Limitations

  • 1Highly heterogeneous studies precluded meta-analysis
  • 2Limited number of randomized clinical trials
  • 3Variability in acupuncture methods used
  • 4Lack of standardization in measured outcomes
  • 5Urgent need for more research in the area
Prof. Dr. Hong Jin Pai

Expert Commentary

Prof. Dr. Hong Jin Pai

PhD in Sciences, University of São Paulo

Clinical Relevance

Pediatric pain remains systematically undertreated, in part due to the scarcity of analgesic options with an adequate safety profile for different age groups. This systematic review covering ten years of scientific production — 22 clinical trials with 1,458 patients — offers pediatricians and pain medicine specialists a structured view of where acupuncture already has sufficient support for clinical integration. The scenarios of greatest immediate relevance are procedural pain in the hospital setting, where reducing opioid and benzodiazepine use is an explicit safety goal, and dysmenorrhea and pelvic pain in adolescents, populations with frequent dissatisfaction with conventional pharmacological treatment. Infant colic, although with heterogeneous results, represents a high-volume clinical demand with few validated alternatives. In all these contexts, the consistently favorable safety profile documented in the studies gives acupuncture a real clinical argument for integration into the multidisciplinary protocol.

Notable Findings

The 82% rate of studies with positive results, in a review with rigorous inclusion criteria applied to an initial base of 598 records reduced to 22 high-quality studies, is a consistent signal — not an artifact of permissive selection. Special attention is warranted for the documented efficacy in procedural pain, a category that concentrated 55% of the studies and ranges from neonatal heel puncture to tonsil surgeries and renal biopsies: contexts where any safe analgesic adjuvant has immediate clinical impact. Another relevant finding is the efficacy of acupressure at point LI-4 for infant colic — a technique that does not require needles and can be taught to caregivers. The diversity of modalities used (filiform needles in 50% of cases, in addition to laser acupuncture, auricular therapy, and electrostimulation) reveals that the pediatric field is already experimenting with methodological adaptations compatible with the particularities of the young patient, which broadens the technical repertoire available to the acupuncturist physician.

From My Experience

In my practice at the HC-FMUSP Pain Center, the demand for pediatric acupuncture has grown substantially in the last decade, driven mainly by families seeking to reduce the pharmacological burden in children with chronic or recurrent pain. For procedural pain, I have advised colleagues to consider acupuncture or acupressure as a pre-procedure adjuvant, especially in children with important anticipatory anxiety — the response is usually noticeable already in the first session, with visible reduction in agitation and pain perception reported by parents. In adolescents with dysmenorrhea refractory to anti-inflammatories, I typically see significant clinical response between the third and fifth session, with monthly maintenance being sufficient after stabilization. For infant colic, I prefer to teach LI-4 acupressure to parents as a home intervention — practical, safe, and compatible with what the data from this review suggest. The profile that responds best, in my observation over the years, is the child over five years old with well-localized pain and an engaged family in follow-up; below this age range, I always adapt the technique to needle-free modalities.

Specialist physician in Medical Acupuncture. Adjunct Professor at the Institute of Orthopedics, HC-FMUSP. Coordinator of the Acupuncture Group at the HC-FMUSP Pain Center.

Full original article

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Journal of Traditional and Complementary Medicine · 2020

DOI: https://doi.org/10.1016/j.jtcme.2019.08.004

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Scientific Review

Marcus Yu Bin Pai, MD, PhD

Marcus Yu Bin Pai, MD, PhD

CRM-SP: 158074 | RQE: 65523 · 65524 · 655241

PhD in Health Sciences, University of São Paulo. Board-certified in Pain Medicine, Physical Medicine and Rehabilitation, and Medical Acupuncture. Scientific review and curation of every entry in this library.

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Medical disclaimer: This content is for educational purposes only and does not replace consultation, diagnosis, or treatment by a qualified professional. Some information may be assisted by artificial intelligence and is subject to inaccuracies. Always consult a physician.

Content reviewed by the medical team at CEIMEC — Integrated Centre for Chinese Medicine Studies, a reference in Medical Acupuncture for over 30 years.