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The Effectiveness of Acupuncture on Headache Intensity and Frequency in Patients With Tension-Type Headache: A Systematic Review and Meta-Analysis

Kolokotsios et al. · Cureus · 2021

📊Systematic Review and Meta-analysis👥n=1,272 participantsHigh-quality evidence

Evidence Level

MODERATE
75/ 100
Quality
4/5
Sample
3/5
Replication
4/5
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OBJECTIVE

To examine the efficacy of acupuncture on pain intensity and frequency in patients with tension-type headache

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WHO

Adults with tension-type headache (1,272 participants across 15 studies)

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DURATION

Treatments of 4-6 weeks with follow-up of up to 6 months

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POINTS

GB-20, LI-4, LR-3 as principal points, plus optional points on the head, neck, and shoulders

🔬 Study Design

1272participants
randomization

Acupuncture

n=636

Traditional acupuncture, electroacupuncture, or dry needling

Control

n=636

Sham acupuncture, placebo, or other therapies

⏱️ Duration: 4 to 6 weeks of treatment

📊 Results in numbers

-1.53 days/month

Reduction in pain frequency at short term

p=0.35

Statistical significance at short term

-0.41 points on VAS

Reduction in pain intensity at long term

p=0.009

Long-term intensity significance

📊 Outcome Comparison

Pain intensity (VAS 0-10) - Long term

Acupuncture
5.35
Placebo/Sham
5.76

Pain frequency (days/month) - Long term

Acupuncture
6
Placebo/Sham
7.55
💬 What does this mean for you?

This study shows that acupuncture may be useful for reducing the intensity of tension-type headache pain in the long term, but it did not show significant immediate benefits after treatment. For those who suffer from chronic tension-type headaches, acupuncture may offer gradual relief, especially when combined with other therapies.

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Article summary

Plain-language narrative summary

Tension-type headache is considered the most common form of primary headache in adults, significantly affecting patients' quality of life and generating high economic costs for society. Characterized by pain or discomfort in the head region that may radiate to the neck, this condition is frequently related to myofascial trigger points in the muscles of the head and neck, in addition to complex neurological mechanisms involving both peripheral and central nervous system factors. Although various therapeutic approaches are used in treatment, including analgesic medications, physical therapy, and relaxation techniques, acupuncture has gained growing popularity among patients seeking therapeutic alternatives, despite the lack of robust scientific evidence on its efficacy.

This study aimed to scientifically evaluate the effectiveness of acupuncture in the treatment of tension-type headache, specifically analyzing its impact on the intensity and frequency of headache attacks. The researchers conducted a rigorous systematic review of the scientific literature, following established international protocols. The search was performed in four major medical databases between January 2000 and February 2021, initially identifying more than 2,000 scientific articles. After applying rigorous selection criteria, only 15 studies of high methodological quality were included in the analysis, totaling 1,272 participants.

Of these, only four studies with 557 participants met the specific criteria for the statistical meta-analysis, which is a method that combines results from multiple studies to obtain more reliable conclusions. The selected studies compared different types of acupuncture with simulated treatments or other interventions, evaluating both immediate results after the end of treatment and long-term effects.

The meta-analysis results revealed important findings, but also some limitations in the efficacy of acupuncture. In the period immediately after the end of treatment, acupuncture did not demonstrate statistically significant superiority over control groups in reducing the frequency of headache attacks. The mean difference observed was a reduction of approximately 1.5 headache days per month, but this result did not reach statistical significance. Similarly, pain intensity, measured through visual analog scales, showed only a small immediate improvement that was not statistically significant.

However, when the researchers analyzed long-term effects, they found more promising results. After an average follow-up period of two months, acupuncture demonstrated statistically significant benefit in reducing pain intensity, with a mean decrease of 0.41 points on the pain scale. Although a reduction in attack frequency was also observed in the long term, this result was at the borderline of statistical significance.

For patients suffering from tension-type headache, these findings suggest that acupuncture may offer benefits, especially when long-term effects are considered. The significant improvement in pain intensity after a few months may represent important relief for those living with chronic headaches. It is important to note that acupuncture demonstrated greater efficacy when combined with other therapies, such as physical therapy or specific exercises, suggesting that an integrated approach may be more beneficial than treatment in isolation. For health professionals, these results indicate that acupuncture can be considered as part of a comprehensive therapeutic plan, especially for patients seeking alternatives to conventional medications or who do not respond adequately to other treatments.

The dry needling technique, a modality related to acupuncture, showed more consistent results in the analyzed studies, suggesting that different needle stimulation techniques may have distinct efficacies.

The study presents some important limitations that should be considered in the interpretation of the results. The relatively small number of studies eligible for meta-analysis and the small sample sizes in many of the individual studies may have limited the ability to detect statistically significant differences between groups. In addition, the heterogeneity of acupuncture protocols used in the different studies, including variations in application points, frequency, and duration of treatment, may have influenced the results. The inherent difficulty in creating truly blinded control groups in acupuncture studies also represents a methodological challenge, since both patients and therapists can often identify whether the treatment is real or simulated.

The authors acknowledge that future studies with larger samples and more standardized protocols are needed to confirm and expand these findings, particularly with respect to effects on the frequency of headache attacks, where the results remained inconclusive.

Strengths

  • 1Robust meta-analysis with rigorous selection criteria
  • 2Included studies of high methodological quality (PEDro)
  • 3Analysis of both short- and long-term outcomes
  • 4Low heterogeneity between studies
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Limitations

  • 1Limited number of studies eligible for meta-analysis (only 4)
  • 2Small sample size in most studies
  • 3Difficulty in blinding therapists due to the nature of the intervention
  • 4Many studies excluded due to language limitations
Dr. Marcus Yu Bin Pai

Expert Commentary

Dr. Marcus Yu Bin Pai

MD, PhD · Pain Medicine · Physical Medicine and Rehabilitation · Medical Acupuncture

Clinical Relevance

Tension-type headache occupies a central place in pain and rehabilitation clinics, frequently coexisting with cervical myofascial syndrome and temporomandibular dysfunction — a clinical profile that challenges any monotherapy. The most relevant data from this meta-analysis for daily practice is the significant reduction in pain intensity at long-term follow-up (p=0.009), precisely the time horizon that most matters to the chronic patient. The ideal candidate profile is the adult with recurrent tension-type headache who has either exhausted or cannot tolerate frequent-use analgesics, or who presents risk of medication-overuse headache. Acupuncture positions itself well in this context as a component of a multimodal plan, alongside cervical physical therapy, sleep hygiene, and autonomic regulation strategies — without conflicting with ongoing pharmacologic treatment.

Notable Findings

The temporal pattern of the results deserves attention: the absence of statistical significance at short term (p=0.35 for frequency) contrasts with the significant benefit in long-term intensity (p=0.009), suggesting that acupuncture acts through mechanisms of neuroplasticity and central modulation that require time to consolidate — a hypothesis compatible with what we know about descending pain regulation and central sensitization in chronic tension-type headache. The 0.41-point reduction on VAS may seem modest in absolute terms, but in populations with low-intensity, high-frequency chronic pain, this delta has real functional impact. The superior performance of dry needling in the analyzed studies also draws attention, reinforcing the hypothesis that deactivation of pericranial and cervical myofascial trigger points is a central pathophysiological mechanism in this condition.

From My Experience

In my practice in the musculoskeletal pain clinic, chronic tension-type headache associated with active trigger points in the upper trapezius, sternocleidomastoid, and suboccipitals is one of the scenarios in which I most indicate systematic acupuncture. I usually observe perceptible response — reduction of intensity and improvement of sleep — starting from the third or fourth session, with consolidation of benefit between the eighth and twelfth sessions, which is consistent with the long-term pattern found in this meta-analysis. I routinely combine it with cervical kinesiotherapy and postural reeducation work, since maintenance of biomechanical dysfunction sabotages any result of needling. I avoid indicating acupuncture as monotherapy in patients with an untreated generalized anxiety component or ongoing medication-overuse headache — in these cases, pharmacologic intervention precedes needling. The profile that responds best, in my experience, is the patient with high-frequency episodic headache, without analgesic overuse, and with evident cervical myofascial burden on physical examination.

PhD in Health Sciences, University of São Paulo. Board-certified in Pain Medicine, Physical Medicine and Rehabilitation, and Medical Acupuncture.

Full original article

Read the full scientific study

Cureus · 2021

DOI: 10.7759/cureus.14237

Access original article

Scientific Review

Marcus Yu Bin Pai, MD, PhD

Marcus Yu Bin Pai, MD, PhD

CRM-SP: 158074 | RQE: 65523 · 65524 · 655241

PhD in Health Sciences, University of São Paulo. Board-certified in Pain Medicine, Physical Medicine and Rehabilitation, and Medical Acupuncture. Scientific review and curation of every entry in this library.

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Medical disclaimer: This content is for educational purposes only and does not replace consultation, diagnosis, or treatment by a qualified professional. Some information may be assisted by artificial intelligence and is subject to inaccuracies. Always consult a physician.

Content reviewed by the medical team at CEIMEC — Integrated Centre for Chinese Medicine Studies, a reference in Medical Acupuncture for over 30 years.