Effectiveness of Manual Therapy and Acupuncture in Tension-Type Headache: A Systematic Review
Turkistani et al. · Cureus · 2021
Evidence Level
MODERATEOBJECTIVE
To assess the efficacy of acupuncture and manual therapy in the treatment of tension-type headaches
WHO
Adults with episodic or chronic tension-type headache
DURATION
Studies with 6 weeks to 12 months of follow-up
POINTS
GB-20 (Fengchi), GV-20 (Baihui), EX-HN5 (Taiyang), LI-4 (Hegu), LR-3 (Taichong)
🔬 Study Design
True acupuncture
n=1200
Needling at specific points
Manual therapy
n=1300
Massage, cervical mobilization, and exercises
Controls
n=1346
Usual care or placebo
📊 Results in numbers
Reduction in headache frequency (acupuncture)
Reduction in headache frequency (manual therapy)
Patient-reported effectiveness (manual therapy)
Improvement with acupuncture vs. placebo
Percentage highlights
📊 Outcome Comparison
Reduction in headache frequency (%)
This study shows that both acupuncture and manual therapy (massage and mobilization) can be effective treatments for tension-type headaches. Patients who received these treatments had a significant reduction in the frequency of headaches, with few side effects compared with medications.
Article summary
Plain-language narrative summary
Tension-type headache is one of the most common forms of headache, affecting a significant portion of the world population. Characterized by continuous pain, like a pressure or tightening around the head, generally described by patients as a "tight band" on the forehead, neck, and shoulders, this condition can cause considerable impact on people's quality of life. Although it is more frequent in adult women, it can affect people of any age. The exact mechanism that causes these headaches is not yet completely clear, but muscle tension, frequently related to stress and anxiety, is believed to play a fundamental role.
With an estimated prevalence of 36% to 78% among all headaches, and considering that approximately 90% of people have experienced some type of headache during their lives, it becomes evident the importance of finding effective and safe treatments for this condition.
This study had as its main objective to evaluate the effectiveness of two specific non-pharmacological approaches in the treatment of tension-type headache: acupuncture and manual therapy. To this end, the researchers conducted a systematic review, following rigorous criteria of scientific analysis. The search for studies was performed mainly in the PubMed database, considering research published between 2011 and 2021, in English, involving only adults aged 19 years or older. Different types of studies were included, such as randomized clinical trials, observational studies, and systematic reviews.
After applying specific inclusion and exclusion criteria, the researchers selected eight articles that involved a total of 3,846 participants. The quality of the studies was evaluated by two independent researchers, using internationally recognized scales to ensure the reliability of the results.
The results demonstrated promising evidence for both treatments evaluated. Regarding acupuncture, the studies showed that patients who received true acupuncture presented a 50% reduction in headache frequency, compared with 43% reduction in the group that received simulated acupuncture or only usual care. In addition to the decrease in frequency, significant improvement was observed in quality of life, functional capacity, and general state of health of patients treated with acupuncture. Interestingly, although acupuncture proved to be effective, it did not demonstrate superiority over physical therapy, exercise, or massage therapy.
Regarding manual therapy, which includes techniques such as massage, cervical spine manipulation, and mobilization, the results were equally encouraging. Studies conducted in different countries showed a statistically significant decrease in headache intensity, with some patients showing up to 24% reduction in pain intensity 24 hours after treatment with massage. The effectiveness of manual therapy proved to be comparable to preventive medications and tricyclic antidepressants traditionally used in the treatment of tension-type headache.
For patients suffering from tension-type headache, these results represent a valuable perspective of relief through natural and less invasive approaches. Acupuncture, an ancient practice of Chinese medicine, offers a safe alternative with few side effects compared with conventional medications. The most common adverse effects include small bruises, localized pain, and swelling at needle insertion sites, but these symptoms are temporary and self-limited. For health professionals, these findings suggest that both acupuncture and manual therapy may be incorporated as complementary or alternative treatment options, especially for patients who prefer to avoid medications or who do not respond adequately to conventional treatments.
Manual therapy, in particular, has been shown to be widely used and accessible, being reported as effective by 17% to 82% of patients in different studies, with an average of 42.5% improvement. It is important to highlight that the combination of different approaches, such as acupuncture associated with postural exercises and physical therapy, demonstrated even more significant results in reducing the frequency and intensity of pain.
Despite the promising results, the study presents some important limitations that should be considered in the interpretation of the findings. One of the main difficulties faced by the researchers was the standardization of treatments, since both acupuncture and manual therapy can vary significantly in terms of techniques applied, points treated, and duration of treatments. In addition, the conduct of double-blind studies (where neither the patient nor the therapist knows which treatment is being applied) is practically impossible in these therapeutic modalities, which can influence the results. The lack of standardized protocols also makes direct comparison between different studies difficult.
The researchers also acknowledge that data on long-term benefits are limited, and that more research is needed to establish the optimal duration of treatments and the maintenance of benefits over time. Despite these limitations, the available evidence strongly suggests that both acupuncture and manual therapy represent valuable options in the therapeutic arsenal for the treatment of tension-type headache, offering patients safe and effective alternatives that can significantly improve their quality of life and reduce dependence on medications.
Strengths
- 1Large number of participants (3,846)
- 2Inclusion of multiple types of controlled studies
- 3Evaluation of two complementary therapeutic modalities
- 4Long-term follow-up in some studies
Limitations
- 1Difficulty of blinding in manual therapy studies
- 2Lack of standardization in treatment protocols
- 3Variable methodological quality among included studies
- 4Limitation to English-language studies only
Expert Commentary
Dr. Marcus Yu Bin Pai
MD, PhD · Pain Medicine · Physical Medicine and Rehabilitation · Medical Acupuncture
▸ Clinical Relevance
Tension-type headache represents one of the most frequent diagnoses in pain and rehabilitation clinics, and the question of when to indicate non-pharmacological approaches as the main line — and not as a late complement — is central to our practice. This review, gathering 3,846 participants in eight controlled studies, reinforces that both acupuncture and manual therapy have documented efficacy and a safety profile superior to that of long-standing pharmacological options, such as tricyclic antidepressants. The data showing that manual therapy proved to be comparable to these medications in terms of preventive effectiveness is clinically relevant for patients who present cardiac contraindications, glaucoma, or intolerance to anticholinergic effects. The 50% reduction in attack frequency with true acupuncture, with statistical significance versus placebo, offers solid backing for indicating the modality in patients with frequent episodic or chronic headache, especially when there is overlap with cervical myofascial dysfunction and a central sensitization component.
▸ Notable Findings
The breadth of the effectiveness range reported for manual therapy — from 17% to 82% across studies — reflects the real heterogeneity of populations with tension-type headache and, more than a weakness, indicates that specific subgroups respond very expressively. The data of 77% reduction in attack frequency with manual therapy in certain studies is extraordinary for a non-pharmacological treatment. Another finding that deserves attention is the absence of superiority of acupuncture over physical therapy, exercise, and massage therapy: this does not diminish its value — on the contrary, it suggests that the mechanism of central pain modulation can be reached by multiple physical pathways, which strengthens multimodal strategies. The 24% reduction in pain intensity in the first 24 hours after massage indicates a relevant acute effect, applicable to attack management in contexts where the patient seeks rapid relief without resorting to oral analgesia.
▸ From My Experience
In my practice in the musculoskeletal pain clinic, tension-type headache with a cervical myofascial component is one of the scenarios in which I usually see earlier response to acupuncture — frequently from the third or fourth session there is already a report of reduction in the weekly frequency of attacks. For maintenance, I usually work with cycles of 10 to 12 sessions, followed by monthly reinforcement sessions in patients with a chronic pattern. I have systematically combined acupuncture with postural guidance, cervical stabilization exercises, and, when there is an active trigger point in the upper trapezius or splenius, I include direct dry needling before moving to distal points. The profile of patient that responds best, in my experience, is the one with frequent episodic headache, an identifiable cervicogenic component on physical examination, and a history of analgesic overuse — exactly the group in which we want to avoid chronification through medication overuse. The findings of this review are consistent with what we have observed clinically for years.
Full original article
Read the full scientific study
Cureus · 2021
DOI: 10.7759/cureus.17601
Access original articleScientific Review

Marcus Yu Bin Pai, MD, PhD
CRM-SP: 158074 | RQE: 65523 · 65524 · 655241
PhD in Health Sciences, University of São Paulo. Board-certified in Pain Medicine, Physical Medicine and Rehabilitation, and Medical Acupuncture. Scientific review and curation of every entry in this library.
Learn more about the author →Medical disclaimer: This content is for educational purposes only and does not replace consultation, diagnosis, or treatment by a qualified professional. Some information may be assisted by artificial intelligence and is subject to inaccuracies. Always consult a physician.
Content reviewed by the medical team at CEIMEC — Integrated Centre for Chinese Medicine Studies, a reference in Medical Acupuncture for over 30 years.
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