Effects from acupuncture in treating anxiety: integrative review

Goyatá et al. · Revista Brasileira de Enfermagem · 2016

📊Integrative Review📋n = 19 included studiesModerate Evidence

Evidence Level

MODERATE
68/ 100
Quality
3/5
Sample
3/5
Replication
4/5
🎯

OBJECTIVE

Evaluate the scientific evidence on the effects of acupuncture in the treatment of anxiety and the quality of the studies

👥

WHO

Diverse populations: women with breast cancer, mothers of premature infants, primary care patients, military personnel

⏱️

DURATION

Review of studies published between 2001 and 2014

📍

POINTS

Diverse: Shenmen, auricular relaxation points, traditional TCM points

🔬 Study Design

19participants
randomization

Included studies

n=19

Literature review in multiple databases

RCTs analyzed

n=6

Randomized clinical trials on acupuncture

⏱️ Duration: Review of 13 years of publications

📊 Results in numbers

0%

Studies with strong evidence

0%

RCTs of reasonable quality

All RCTs

Significant positive effects

0

Studies with nurse acupuncturists

Percentage highlights

57.9%
Studies with strong evidence
83.3%
RCTs of reasonable quality

📊 Outcome Comparison

Study Quality (QSAT)

Reasonable Quality
5
Low Quality
1

Level of Evidence

Strong Evidence (I)
11
Moderate Evidence (III-IV)
4
Weak Evidence (V-VI)
4
💬 What does this mean for you?

This review analyzed 19 studies on acupuncture for anxiety and found that the technique showed positive and significant effects in different groups of people. Although promising, the quality of the studies still needs to improve to provide more robust evidence on its efficacy.

📝

Article summary

Plain-language narrative summary

Anxiety is a very common health problem today, characterized by unpleasant feelings of restlessness, tension, and apprehension that tend to become chronic. This condition can appear in different clinical situations, such as generalized anxiety disorder, panic syndrome, post-traumatic stress disorder, phobias, and obsessive-compulsive disorder, and is related to other diseases such as cardiac problems, gastrointestinal problems, and asthma. The high prevalence of anxiety in the general population, especially its tendency to chronicity and the social and individual costs involved, has made the search for effective and safe treatments essential. Conventional treatments include mainly anxiolytic medications, such as benzodiazepines, which are widely prescribed worldwide, but present important concerns related to physical, chemical, and psychological dependence, mainly when used for prolonged periods or in inadequate doses.

The present study aimed to evaluate the scientific evidence available in the literature on the effects of acupuncture in the treatment of anxiety and to analyze the methodological quality of this research. The researchers performed an integrative literature review, which is an evidence-based research method that allows the incorporation of scientific knowledge into clinical practice. The search was conducted in five important scientific databases between April and June 2014, including studies published between 2001 and 2014. They used specific keywords such as anxiety, acupuncture, and acupuncture therapy, strategically combined to ensure a broad search of primary studies.

Articles in Portuguese, English, and Spanish that answered the research question and were electronically available were included.

The results showed that, of 514 articles initially found, 19 were included in the final analysis after rigorous application of the selection criteria. The majority of studies were conducted in the United States, followed by Brazil, with representation also from other countries such as Canada, the United Kingdom, Australia, Sweden, Turkey, Austria, and Israel. Among the studies analyzed, 11 presented a strong level of scientific evidence, of which six were randomized controlled clinical trials. When these six studies were evaluated for methodological quality using a specific scale for acupuncture research, five were classified as of reasonable quality and one as of low quality.

The number of participants in the studies ranged from 29 to 120 people, and validated instruments were used to measure anxiety. The results demonstrated positive and statistically significant effects of the use of acupuncture for the treatment of people with anxiety, with significant improvements compared with conventional treatments.

The clinical implications of these findings are promising for both patients and health professionals. Acupuncture was shown to be a safe and effective therapeutic alternative, without the side effects associated with traditional anxiolytic medications, such as dependence or drowsiness. For patients, this means a treatment option that can be used alone or in combination with other therapies, offering relief from anxious symptoms without the risks of conventional medications. The World Health Organization had already recognized acupuncture since 2002 as effective for the treatment of various health problems, including psychological and emotional disorders, validating its use in different age groups and levels of health care.

In Brazil, acupuncture was included in the National Policy on Integrative and Complementary Practices (PNPIC) of the Unified Health System (SUS) in 2006, and nursing professionals have been able to practice it as a specialty since 2008, which expands access to this therapy.

Despite the encouraging results, the study has some important limitations that must be considered. The main limitation refers to the methodological quality of the research analyzed, with problems such as small samples, lack of standardization in treatment protocols, diversity of instruments to assess anxiety, and absence of a gold standard in treatments. Some studies had deficiencies in randomization, blinding of participants, and clear definition of the number of sessions and duration of treatment. Another limitation was the restriction of the search to articles in only three languages, which may have excluded important studies published in Eastern countries where acupuncture is a traditional medical practice.

The authors conclude that, although acupuncture appears to be a promising treatment for anxiety, there is a need to improve the methodological quality of research in this area, with studies of greater scientific rigor, larger samples, and more standardized protocols, so that more precise and safe clinical guidelines can be established for the use of this therapy in the treatment of anxiety.

Strengths

  • 1Comprehensive analysis of multiple international databases
  • 2Use of a specific tool (QSAT) to evaluate the quality of acupuncture studies
  • 3Majority of studies (57.9%) with a strong level of evidence
  • 4Consistent results showing positive effects of acupuncture
  • 5Inclusion of studies with nurse acupuncturists
⚠️

Limitations

  • 1Variable methodological quality of primary studies
  • 2Lack of standardization in treatment protocols
  • 3Small sample sizes in the RCTs (29-120 participants)
  • 4Diversity of instruments to assess anxiety
  • 5Language limitation (Portuguese, English, Spanish)
Prof. Dr. Hong Jin Pai

Expert Commentary

Prof. Dr. Hong Jin Pai

PhD in Sciences, University of São Paulo

Clinical Relevance

Anxiety is one of the most prevalent conditions in the daily practice of any pain or integrative medicine service, and frequently arrives at the clinic refractory to or intolerant of conventional anxiolytics. This integrative review, by consolidating 19 studies published over thirteen years and demonstrating consistent positive effects in all randomized clinical trials analyzed, offers the clinician a reasonable basis to support the indication of acupuncture as an adjuvant or alternative therapy. The fact that 57.9% of the studies showed a strong level of evidence is sufficiently encouraging for specific populations: patients who refuse pharmacotherapy, pregnant patients with restriction on the use of benzodiazepines, elderly patients with polypharmacy, and individuals with anxiety secondary to chronic painful conditions. In these scenarios, acupuncture fits naturally into the available therapeutic arsenal, complementing or replacing interventions whose risk profile is more significant.

Notable Findings

The most notable finding of this review is the unanimity of positive results among the six randomized clinical trials evaluated — all demonstrated statistically significant effects of acupuncture on anxiety outcomes. This level of consistency, even in the face of heterogeneous protocols, suggests robustness of the effect and should not be underestimated. Another point that deserves attention is the evaluation by the QSAT instrument, specific to acupuncture research: five of the six RCTs achieved reasonable quality, which positions the available evidence base above what is often assumed. The geographic breadth of the studies — United States, Brazil, Canada, United Kingdom, Australia, among others — points to a moderate generalization of the findings. The favorable safety profile, without the risks of dependence associated with benzodiazepines, is a concrete clinical differential that this review reinforces with coherence.

From My Experience

In my practice in the Acupuncture Group of the Pain Center of HC-FMUSP, anxiety rarely presents as an isolated complaint — it accompanies chronic pain with a frequency that, over the decades, has come to surprise me less and guide me more. I have observed that patients with a prominent anxious component tend to respond to acupuncture within three to five sessions with noticeable improvement in sleep and autonomic reactivity, even before any change in formal anxiety scores. The protocol I usually associate includes points such as Yintang, Shenmen (HT-7), Neiguan (PC-6), and Zusanli (ST-36), frequently combined with low-frequency electroacupuncture in the initial sessions. On average, I conduct eight to twelve sessions until stabilization, with monthly maintenance in chronic cases. The combination with cognitive-behavioral techniques and aerobic physical activity potentiates the results in a way that none of the isolated interventions usually matches. Patients with a hyperreactive profile to the needle stimulus or with active panic disorder require a more cautious initial approach — in these cases, I prefer auricular acupuncture as the gateway before advancing to the full body protocol.

Specialist physician in Medical Acupuncture. Adjunct Professor at the Institute of Orthopedics, HC-FMUSP. Coordinator of the Acupuncture Group at the HC-FMUSP Pain Center.

Full original article

Read the full scientific study

Revista Brasileira de Enfermagem · 2016

DOI: http://dx.doi.org/10.1590/0034-7167.2016690325i

Access original article

Scientific Review

Marcus Yu Bin Pai, MD, PhD

Marcus Yu Bin Pai, MD, PhD

CRM-SP: 158074 | RQE: 65523 · 65524 · 655241

PhD in Health Sciences, University of São Paulo. Board-certified in Pain Medicine, Physical Medicine and Rehabilitation, and Medical Acupuncture. Scientific review and curation of every entry in this library.

Learn more about the author →
⚕️

Medical disclaimer: This content is for educational purposes only and does not replace consultation, diagnosis, or treatment by a qualified professional. Some information may be assisted by artificial intelligence and is subject to inaccuracies. Always consult a physician.

Content reviewed by the medical team at CEIMEC — Integrated Centre for Chinese Medicine Studies, a reference in Medical Acupuncture for over 30 years.