Effects of Acupuncture in Ischemic Stroke Rehabilitation: A Randomized Controlled Trial
Li et al. · Frontiers in Neurology · 2022
Evidence Level
STRONGOBJECTIVE
To evaluate the efficacy of acupuncture in the rehabilitation of patients with ischemic stroke in a multicenter study
WHO
497 patients with ischemic stroke (2 weeks to 12 months after the acute event)
DURATION
2 weeks of treatment, 1 session/day, 5 days/week, with 4 weeks of follow-up
POINTS
Group 1: GV-20, GV-26, PC-9, ST-6, ST-4, LI-15, LI-11, LI-4, GB-30, GB-31, GB-34, GB-39; Group 2: GV-20, PC-6, LI-11, LI-10, TE-5, LI-4, GB-30, ST-36, GB-34, SP-6, ST-41, LR-3
🔬 Study Design
Acupuncture Group 1 (classical points)
n=159
Acupuncture based on classical texts + rehabilitation
Acupuncture Group 2 (modern points)
n=173
Acupuncture based on modern literature + rehabilitation
Control Group
n=165
Conventional rehabilitation only
📊 Results in numbers
NIHSS reduction (Group 1 vs Control)
BI improvement (Group 2 vs Control)
Adverse-event rate
Minor bleeding
Percentage highlights
📊 Outcome Comparison
NIHSS (neurological scale)
Barthel Index (independence)
This study demonstrated that acupuncture can accelerate recovery after ischemic stroke. Patients who received acupuncture alongside rehabilitation had better neurological recovery and greater independence in daily activities compared with those who received rehabilitation alone. The treatment was safe, with only minor adverse events.
Article summary
Plain-language narrative summary
Acupuncture is an ancient form of treatment that has been gaining growing scientific recognition for the management of various neurological conditions, especially recovery after stroke. Ischemic stroke is one of the leading causes of disability and death worldwide, affecting hundreds of thousands of people each year. In China, where this study was conducted, stroke incidence is particularly high, affecting between 274 and 379 people per 100,000 inhabitants, with 60% to 70% of cases being ischemic in origin. Three quarters of stroke survivors are left with some degree of disability, and approximately 40% develop severe disabilities that significantly impact their quality of life and ability to perform daily activities.
Faced with this concerning reality, Chinese researchers conducted a randomized controlled clinical trial to investigate whether acupuncture could offer additional benefits when combined with conventional rehabilitation for patients recovering from ischemic stroke. The main objective was to compare the efficacy of two different acupuncture protocols: one based on classical texts of traditional Chinese medicine and another based on modern scientific literature. The study evaluated 497 patients with ischemic stroke across three different hospitals in China, randomly dividing them into three groups. The first treatment group received acupuncture based on points described in classical texts, the second group used points selected based on contemporary scientific literature, and the third group served as control, receiving conventional rehabilitation alone.
The study methodology was carefully planned to ensure scientific validity of the results. The acupuncture points were selected by specialists based on their historical efficacy and scientific evidence. In the first protocol, twelve specific points were used, including Baihui at the top of the head, traditionally used to "awaken the brain and pacify the spirit," and other points along the yang meridians of the body. The second protocol also used twelve points, but selected based on modern scientific studies.
All groups received treatment five times per week for two weeks, with needles remaining in place for 30 minutes per session. Treatment efficacy was measured using standardized scales that evaluate different aspects of stroke recovery: severity of neurological deficits, ability to perform activities of daily living, and degree of muscle stiffness.
The study results were promising and revealed distinct benefits for each acupuncture protocol. The first treatment group, which used points based on classical texts, showed significant improvement in neurological deficits compared with the control group. This means these patients had better recovery of functions such as movement, speech, and coordination. The second treatment group, based on modern literature, showed superiority over the control group in the ability to perform daily activities such as dressing, eating, and walking.
Interestingly, both acupuncture protocols showed similar efficacy to each other, suggesting that different approaches may have specific strengths in stroke recovery. With respect to muscle stiffness, although there was a trend toward improvement in all groups, no statistically significant differences were found between the treatment and control groups.
From a safety standpoint, the study demonstrated that acupuncture is a safe treatment when performed by qualified practitioners. Only minor adverse events were recorded, such as small bleeds at the needle insertion site and occasional needles becoming "stuck" because of muscle tension. These issues were easily resolved by the acupuncturists, and no patient withdrew from the study because of side effects. Laboratory tests performed during treatment showed no significant changes in vital functions such as liver, kidney, or heart, confirming the favorable safety profile of acupuncture.
For patients and families, these results suggest that acupuncture may be a valuable addition to conventional rehabilitation treatment after ischemic stroke. The therapy was shown to accelerate neurological recovery and improve functional independence, both of which are crucial aspects of quality of life after a stroke. For health care professionals, the study provides robust scientific evidence regarding the efficacy of specific acupuncture protocols, offering practical guidance on when and how to incorporate this therapy into the treatment plan. The fact that different protocols showed benefits in distinct aspects of recovery suggests that the approach can be personalized according to each patient's specific needs.
It is important to acknowledge the limitations of this study to interpret the findings appropriately. The treatment period was relatively short, only two weeks, and it is possible that additional benefits could emerge with longer treatments. Furthermore, because of the nature of acupuncture, it was not possible to make the study completely "blinded" — that is, both patients and acupuncturists knew which treatment was being administered, which may have influenced the results in some way. Patient follow-up was also limited to four weeks after the start of treatment, not allowing evaluation of long-term benefits.
In conclusion, this study represents a significant contribution to the scientific understanding of acupuncture in the treatment of ischemic stroke. The results suggest that different acupuncture protocols can effectively complement conventional rehabilitation, offering specific benefits in neurological and functional recovery. For patients recovering from stroke, this means that acupuncture can be considered a safe and effective therapeutic option, especially when integrated into a comprehensive rehabilitation program. Future studies with longer treatment periods and extended follow-up may provide additional insights into the full potential of this ancient therapy within modern medicine.
Strengths
- 1Large multicenter sample (497 patients)
- 2Comparison among different acupuncture protocols
- 3Adequate follow-up with validated scales
- 4Low study dropout rate
Limitations
- 1Not a double-blind study
- 2Relatively short treatment period (2 weeks)
- 3Inability to blind acupuncturists and patients
- 4Follow-up of only 4 weeks
Expert Commentary
Dr. Marcus Yu Bin Pai
MD, PhD · Pain Medicine · Physical Medicine and Rehabilitation · Medical Acupuncture
▸ Clinical Relevance
Post-ischemic-stroke rehabilitation remains one of the greatest challenges in physical medicine, especially considering that three quarters of survivors carry some degree of residual disability. This trial, conducted across three centers with 497 patients, offers a practical answer to a question rehabilitation services face daily: does acupuncture add measurable clinical value when combined with the conventional program? The data say yes, with improvement in the NIHSS in the group that used classical-text-based points and improvement in the Barthel Index in the group with points selected by modern evidence. For the physiatrist, this translates into two distinct therapeutic targets: neurological recovery and functional independence. The safety profile of 2.4% minor adverse events, with no need for treatment interruption, makes this combination feasible for fragile populations, including older adults with multiple comorbidities, who make up the bulk of our post-stroke patients.
▸ Notable Findings
The most thought-provoking finding of this work is not simply that acupuncture works in post-stroke recovery, but that the two protocols demonstrated distinct and complementary benefit profiles. The classical-points group, centered on points such as Baihui and the yang meridians, showed superiority in reducing neurological deficits as measured by the NIHSS, while the modern-literature-based group showed a functional advantage on the Barthel Index. This dissociation between neurological recovery and functional independence is clinically relevant: it suggests that point selection can be guided by each patient's priority therapeutic goal at each phase of recovery. Additionally, the absence of significant difference in spasticity across the groups reinforces that the functional gain observed is not explained solely by tone reduction, pointing to central mechanisms of neuroplasticity as the more consistent hypothesis.
▸ From My Experience
In my practice in neurological rehabilitation, I have been incorporating acupuncture as an adjuvant in post-stroke care for more than fifteen years, and the response pattern I observe converges substantially with what this trial documents. I usually see the first signs of functional improvement between the third and fifth session, generally expressed as greater engagement in physical therapy tasks and improved quality of voluntary movement, especially in the upper limbs. The protocol I use in our service combines acupuncture three times per week with daily sessions of motor physical therapy and occupational therapy, which potentiates the gains of both approaches. Patients in the early subacute phase, between two and eight weeks post-event, respond more robustly than those in the established chronic phase. In patients with severe spasticity, grade 3 or 4 on the Ashworth scale, I prefer to combine botulinum toxin before initiating acupuncture, to create a window of mobility that makes the sessions more productive. For functional maintenance, I work with cycles of ten to twelve monthly sessions after the intensive phase.
Full original article
Read the full scientific study
Frontiers in Neurology · 2022
DOI: 10.3389/fneur.2022.897078
Access original articleScientific Review

Marcus Yu Bin Pai, MD, PhD
CRM-SP: 158074 | RQE: 65523 · 65524 · 655241
PhD in Health Sciences, University of São Paulo. Board-certified in Pain Medicine, Physical Medicine and Rehabilitation, and Medical Acupuncture. Scientific review and curation of every entry in this library.
Learn more about the author →Medical disclaimer: This content is for educational purposes only and does not replace consultation, diagnosis, or treatment by a qualified professional. Some information may be assisted by artificial intelligence and is subject to inaccuracies. Always consult a physician.
Content reviewed by the medical team at CEIMEC — Integrated Centre for Chinese Medicine Studies, a reference in Medical Acupuncture for over 30 years.
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