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The Effect of Acupuncture on the Quality of Life in Patients With Migraine: A Systematic Review and Meta-Analysis

Jiang et al. · Frontiers in Pharmacology · 2018

📊Systematic Review with Meta-Analysis👥n=4,947 participants🌟High Clinical Impact

Evidence Level

MODERATE
75/ 100
Quality
3/5
Sample
5/5
Replication
4/5
🎯

OBJECTIVE

To evaluate the efficacy of manual acupuncture in the treatment and prevention of migraine compared with medications and sham acupuncture

👥

WHO

4,947 patients with migraine diagnosed according to international criteria, from 62 studies

⏱️

DURATION

Treatments ranging from less than 1 month to 6 months, with follow-up up to 1 year

📍

POINTS

Main points: Shuaigu (GB-8), Fengchi (GB-20), Yanglingquan (GB-34), Zulinqi (GB-41), Baihui (GV-20), Yintang (GV-29)

🔬 Study Design

4947participants
randomization

True acupuncture

n=2500

Manual acupuncture with filiform needles at specific points

Medication

n=1500

Preventive medications recommended by guidelines

Sham acupuncture

n=947

Superficial needling or needling at incorrect points

⏱️ Duration: 1 to 6 months of treatment

📊 Results in numbers

-1.22 points

Reduction on visual pain scale vs medication (1 month)

-1.56 points

Reduction on visual pain scale vs sham acupuncture (1 month)

+11.56 points

Improvement in quality of life (role restrictive)

19% higher

Total effectiveness rate vs medication

Percentage highlights

19% higher
Total effectiveness rate vs medication

📊 Outcome Comparison

Visual Analog Scale of Pain (0-10)

Acupuncture
3.5
Medication
4.72
Sham acupuncture
5.06
💬 What does this mean for you?

This large analysis of 62 studies shows that acupuncture is more effective than medications and sham acupuncture in reducing pain and improving quality of life in people with migraine. Acupuncture also had fewer side effects than medications, making it a safe and effective option for those who suffer from migraine.

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Article summary

Plain-language narrative summary

This Chinese study analyzed the efficacy of acupuncture in improving the quality of life of people who suffer from migraine, a neurological condition that affects millions of people worldwide. Migraine is considered the third most prevalent disease globally and the seventh leading cause of disability according to international studies. In China, for example, about 9.3% of the population suffers from migraine, generating annual costs of more than 330 billion yuan for the health system. In addition to recurrent physical pain, migraine often causes prolonged psychological stress, anxiety, and tension, creating a vicious cycle that impairs both work and personal life of patients.

Often, conventional medications have limited efficacy and can cause unwanted side effects, making it important to investigate alternative treatments such as acupuncture.

The researchers conducted a systematic review and meta-analysis, which is a type of study that analyzes and combines the results of multiple already published research on the same topic. The main objective was to evaluate whether acupuncture truly improves the quality of life of people with migraine and how it compares with other available treatments. To this end, they searched seven important scientific databases, including PubMed and Cochrane Library, looking for randomized controlled clinical trials published in Chinese and English up to October 2017. Only studies that compared true acupuncture with control groups receiving medications, sham acupuncture, or no treatment were included.

The researchers analyzed 62 studies that involved nearly 5,000 participants, mainly adults, with most studies conducted in China. To evaluate the results, they used various measures such as pain scales, frequency of migraine attacks, specific quality of life questionnaires, and depression scales.

The results showed that acupuncture was consistently superior to other treatments in several important aspects. When compared with conventional medications, acupuncture significantly reduced pain scores on a visual scale up to one month after treatment, and this improvement was maintained for up to three months. Patients treated with acupuncture also had higher overall treatment efficacy rates, both in the short term and at follow-ups of up to six months. When compared with sham acupuncture, where needles are inserted at incorrect points or superficially, true acupuncture demonstrated clear superiority in pain reduction and improvement of migraine-specific quality of life.

The quality of life questionnaires revealed significant improvements in three main areas: limitations in daily activities caused by pain, ability to prevent future attacks, and emotional well-being. In addition, acupuncture reduced the number of migraine days per month and the frequency of attacks. A particularly important aspect was that acupuncture had fewer side effects than conventional medications.

For patients who suffer from migraine, these results are very encouraging and bring important practical implications. Acupuncture can be considered an effective and safe treatment option, especially for people who do not tolerate preventive medications well or who experience significant side effects with pharmacological treatments. The benefits of acupuncture extend beyond simple pain relief, improving fundamental aspects of quality of life such as the ability to work, perform social activities, and maintain emotional well-being. For health professionals, the study provides robust evidence that acupuncture can be integrated into treatment plans for migraine, either as primary or complementary treatment.

The superior safety of acupuncture compared with medications makes it a particularly attractive option for patients who need long-term treatment or who have already experienced adverse effects with other therapies.

However, it is important to recognize some important limitations of this study. The methodological quality of the analyzed studies was variable, with many having problems in experimental design, such as difficulties in keeping patients and researchers truly "blind" about which treatment was being applied. The lack of uniform standards for sham acupuncture also complicates the interpretation of the results, since some procedures considered "sham" may have real therapeutic effects. In addition, the majority of studies included were conducted in China, which may limit the applicability of the results to other populations.

Many studies had small samples and relatively short follow-up periods, and research with longer follow-up is needed to better understand the long-term effects of acupuncture. The researchers also identified great variability among the studies in terms of acupuncture points used, application techniques, and duration of treatment, suggesting the need for standardization of acupuncture protocols for migraine. Despite these limitations, the study represents a comprehensive and current analysis of the available evidence, providing solid scientific support for the use of acupuncture in the treatment of migraine and the improvement of patients' quality of life.

Strengths

  • 1Large sample with nearly 5,000 patients
  • 2Comprehensive analysis comparing multiple treatments
  • 3Quality of life evaluation beyond pain
  • 4Evidence of superior safety compared to medications
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Limitations

  • 1High heterogeneity among studies
  • 2Variable methodological quality of included studies
  • 3Difficulty with adequate blinding
  • 4Most studies were short-term
Dr. Marcus Yu Bin Pai

Expert Commentary

Dr. Marcus Yu Bin Pai

MD, PhD · Pain Medicine · Physical Medicine and Rehabilitation · Medical Acupuncture

Clinical Relevance

Migraine represents one of the greatest challenges in rehabilitation and pain medicine: it is a disabling neurological condition for which the available preventive pharmacological arsenal frequently runs into tolerability and adherence issues. This meta-analysis with nearly 5,000 participants positions acupuncture as a first-line therapeutic alternative, not just as an adjuvant resource for when medications fail. The data are directly applicable to the patient with chronic migraine and analgesic overuse, to the patient who does not tolerate topiramate or propranolol, and to the patient who reports persistent functional impairment between attacks. The 19% superiority in total effectiveness rate compared with medication and the 11.56-point improvement in role-restrictive quality of life provide enough substance to include acupuncture in multidisciplinary headache protocols, integrating planning with neurologists and pain physicians from the preventive phase onward.

Notable Findings

The most clinically significant data of this analysis is not just the pain reduction — which is expected — but the magnitude of improvement in quality of life measurable by the migraine-specific questionnaire, especially in the dimensions of role restriction and emotional well-being. The difference of -1.56 points on the visual pain scale against sham acupuncture is particularly relevant because it establishes that the effect is not attributable solely to expectation or therapeutic ritual, signaling a real neurophysiological substrate. The sustained results up to three months post-treatment compared with medication suggest modification of central sensitization pattern, not just symptomatic analgesia. Another finding worth noting is the safety profile: superiority in adverse effects compared with preventive medications consolidates acupuncture as a rational choice in populations with comorbidities, polypharmacy, or formal pharmacological contraindications.

From My Experience

In my practice at the pain service, I have followed patients with chronic migraine for decades and the response curve I observe is quite consistent with what this analysis suggests: I usually see reduction in attack frequency and intensity between the third and fifth session, with stabilization of functional gain around the twelfth session in an initial intensive protocol. I habitually structure treatment in two phases — induction with two weekly sessions for six weeks, followed by biweekly or monthly maintenance depending on response. I systematically combine this with sleep hygiene counseling and behavioral trigger management, which enhance the result in a way that no isolated intervention can replicate. The profile that responds best, in my experience, is the patient with associated cervical tension component, high degree of central sensitization, and history of adverse effects to pharmacological prophylaxis. I avoid indicating acupuncture as monotherapy in severe acute attacks without rescue pharmacological support; the role here is preventive and quality-of-life modulation, exactly what this work measures.

PhD in Health Sciences, University of São Paulo. Board-certified in Pain Medicine, Physical Medicine and Rehabilitation, and Medical Acupuncture.

Full original article

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Frontiers in Pharmacology · 2018

DOI: 10.3389/fphar.2018.01190

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Scientific Review

Marcus Yu Bin Pai, MD, PhD

Marcus Yu Bin Pai, MD, PhD

CRM-SP: 158074 | RQE: 65523 · 65524 · 655241

PhD in Health Sciences, University of São Paulo. Board-certified in Pain Medicine, Physical Medicine and Rehabilitation, and Medical Acupuncture. Scientific review and curation of every entry in this library.

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Medical disclaimer: This content is for educational purposes only and does not replace consultation, diagnosis, or treatment by a qualified professional. Some information may be assisted by artificial intelligence and is subject to inaccuracies. Always consult a physician.

Content reviewed by the medical team at CEIMEC — Integrated Centre for Chinese Medicine Studies, a reference in Medical Acupuncture for over 30 years.