Acupuncture for Japanese Katakori (Chronic Neck Pain): A Randomized Placebo-Controlled Double-Blind Study

Takakura et al. · Medicina · 2023

🔬Double-Blind Placebo-Controlled RCT👥n=400 participantsHigh level of evidence

Evidence Level

STRONG
88/ 100
Quality
5/5
Sample
5/5
Replication
4/5
🎯

OBJECTIVE

To evaluate whether acupuncture with superficial skin penetration is superior to placebo treatment for essential neck/shoulder stiffness

👥

WHO

400 Japanese patients aged 18-60 with essential neck/shoulder stiffness (katakori)

⏱️

DURATION

Single session with immediate and 24-hour assessment

📍

POINTS

BL-10, GB-21, SI-14, and BL-42 on the more affected side

🔬 Study Design

400participants
randomization

Penetrating acupuncture

n=100

needles penetrating 5 mm into the skin

Placebo skin touch

n=100

needles touching but not penetrating

Placebo no touch

n=100

needles without touching the skin

No-treatment control

n=100

no treatment

⏱️ Duration: 10 minutes of application

📊 Results in numbers

0%

Immediate improvement penetrating acupuncture

0%

24-hour improvement penetrating acupuncture

0%

Immediate improvement placebo touch

0%

24-hour improvement placebo no touch

0%

No-treatment control 24h

Percentage highlights

69%
Immediate improvement penetrating acupuncture
74%
24-hour improvement penetrating acupuncture
73%
Immediate improvement placebo touch
59%
24-hour improvement placebo no touch
22%
No-treatment control 24h

📊 Outcome Comparison

Patients with immediate improvement

Acupuncture
69
Placebo touch
73
Placebo no touch
61
Control
24

Patients with 24-hour improvement

Acupuncture
74
Placebo touch
67
Placebo no touch
59
Control
22
💬 What does this mean for you?

This study showed that acupuncture is effective for neck and shoulder stiffness, working better than no treatment at all. Interestingly, even the acupuncture ritual without penetrating needles had a beneficial effect, but true acupuncture better maintained the benefits after 24 hours.

📝

Article summary

Plain-language narrative summary

This important Japanese study investigated the efficacy of acupuncture in treating chronic stiffness of the neck and shoulders, known in Japan as "katakori," an extremely common condition affecting millions of people. Stiffness of the neck and shoulders is described by patients as a sensation of heaviness, tightness, and discomfort in the muscles supporting the neck, ranking as the second most frequent complaint in Japan, after lumbar pain. This condition has become increasingly prevalent with intensive use of computers and electronic devices in work and daily life.

The primary objective of this research was to scientifically evaluate whether acupuncture with superficial skin penetration truly offers specific benefits compared with placebo treatments, using a rigorously controlled methodology. The researchers conducted a randomized double-blind placebo-controlled study, involving 400 volunteers with essential stiffness of the neck and shoulders. Participants were divided into four groups: treatment with penetrating needles (real acupuncture), treatment with needles that only touch the skin, treatment with needles that do not touch the skin (only the acupuncture ritual), and a control group without any treatment. Six experienced acupuncturists applied the needles at specific points traditionally used for this condition, with each session lasting ten minutes.

The results revealed surprising and clinically relevant findings. All three types of treatment that involved the acupuncture ritual showed significant improvements compared with the group that received no treatment, both immediately after the session and 24 hours later. This included even the group that received only the acupuncture ritual without any needle contact with the skin. However, after 24 hours, treatment with real acupuncture (skin penetration) proved superior to no-touch treatment, indicating that skin penetration has specific effects that last longer.

Interestingly, there was no significant difference between real acupuncture and treatment that only touched the skin, suggesting that even minimal stimuli can have important therapeutic effects.

For patients suffering from chronic stiffness of the neck and shoulders, these results provide valuable information. First, they confirm that acupuncture is effective for this condition, offering a valid therapeutic option, especially considering that conventional medical approaches frequently show limited results. The study also demonstrates that part of the benefits of acupuncture may be related to the ritual and treatment experience itself, which does not diminish its therapeutic validity but helps to better understand how it works. For health care professionals, these findings reinforce the importance of considering both the specific effects of interventions and aspects related to comprehensive patient care.

The study also provides robust evidence on the safety of acupuncture, with only two minor adverse events related to small bleeding.

Several important limitations should be considered when interpreting these results. The study evaluated only a single treatment session with short-duration follow-up, while in clinical practice acupuncture is frequently applied across multiple sessions over weeks. Additionally, superficial insertion of only 5 mm was used, which may not fully represent traditional acupuncture practice that often employs deeper insertions. The researchers also acknowledge that informing patients about the existence of different types of placebo needles may have influenced their perceptions and responses to treatment.

In conclusion, this pioneering study provides robust scientific evidence that acupuncture is effective in treating chronic neck and shoulder stiffness, demonstrating both specific benefits from needle penetration and benefits related to the therapeutic ritual. The results suggest that acupuncture may be a valuable therapeutic option for people suffering from this common condition, especially considering its safety and the scarcity of effective conventional treatments. Future research should explore protocols with multiple sessions and deeper insertions to better understand the full potential of this ancient medical practice in the modern context.

Strengths

  • 1First double-blind placebo-controlled study for cervical stiffness
  • 2Innovative use of three types of needles to test different components
  • 3Large and well-randomized sample
  • 4Rigorous methodology following CONSORT standards
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Limitations

  • 1Only one treatment session
  • 2Short follow-up of only 24 hours
  • 3Superficial insertion of only 5 mm
  • 4Patients knew there were two types of placebo
Dr. Marcus Yu Bin Pai

Expert Commentary

Dr. Marcus Yu Bin Pai

MD, PhD · Pain Medicine · Physical Medicine and Rehabilitation · Medical Acupuncture

Clinical Relevance

Chronic cervical pain with a myofascial component—what the Japanese have systematized as katakori—is one of the most frequent complaints in physiatry and rehabilitation outpatient clinics, especially in office workers with long hours in front of screens. This trial with 400 participants, rigorously controlled and double-blind, provides Level A evidence for acupuncture in this population. The finding that penetrating acupuncture maintained superiority over the no-touch group at 24 hours reinforces that there is a specific neurophysiological component, likely via stimulation of type III and IV mechanoreceptors and supraspinal modulation, that goes beyond the contextual response to the ritual. For current practice, this justifies the inclusion of acupuncture as a first-line option in multimodal protocols for chronic cervical pain, especially when NSAIDs and isolated physical therapy have already been tried with partial response.

Notable Findings

The design with three control arms—skin touch, no touch, and no treatment—is methodologically elegant and allows dissection of the components of the therapeutic response with precision uncommon in the acupuncture literature. The fact that the touch placebo achieved 73% immediate improvement, close to the 69% of penetrating acupuncture, but that the advantage of penetration consolidated at 24 hours with 74% versus 59% for no touch, suggests that minimal cutaneous stimuli already activate rapid analgesic circuits, while tissue penetration recruits mechanisms with slower and more durable kinetics—possibly via local ATP release, modulation of the endogenous opioid system, and descending neuroplasticity. The no-treatment control group with only 22% improvement at 24 hours anchors the entire comparison and rules out spontaneous remission as an explanation for the results.

From My Experience

In my practice at the musculoskeletal pain clinic, chronic cervical pain with predominant stiffness and myofascial tension—exactly the katakori profile—responds well to acupuncture in combination with dry needling of trigger points in the upper trapezius and levator scapulae. I usually see clinically perceptible response within the first three or four sessions, with stabilization around eight to ten sessions for most patients. The profile that responds best is the young adult to middle-aged patient, without associated radiculopathy, with evident postural and occupational overload components. The 74% improvement at 24 hours with a single 10-minute session is consistent with what I observe after initial sessions: early relief is real and sustained enough to engage the patient in the program. I routinely combine it with postural guidance, cervical stabilization exercises, and, when necessary, low-dose cyclobenzaprine in the first weeks. I avoid acupuncture as a sole therapy in patients with cervical pain of important structural origin—herniations with myelopathy or atlantoaxial instability—where the priority is different.

PhD in Health Sciences, University of São Paulo. Board-certified in Pain Medicine, Physical Medicine and Rehabilitation, and Medical Acupuncture.

Full original article

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Medicina · 2023

DOI: 10.3390/medicina59122141

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Scientific Review

Marcus Yu Bin Pai, MD, PhD

Marcus Yu Bin Pai, MD, PhD

CRM-SP: 158074 | RQE: 65523 · 65524 · 655241

PhD in Health Sciences, University of São Paulo. Board-certified in Pain Medicine, Physical Medicine and Rehabilitation, and Medical Acupuncture. Scientific review and curation of every entry in this library.

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Medical disclaimer: This content is for educational purposes only and does not replace consultation, diagnosis, or treatment by a qualified professional. Some information may be assisted by artificial intelligence and is subject to inaccuracies. Always consult a physician.

Content reviewed by the medical team at CEIMEC — Integrated Centre for Chinese Medicine Studies, a reference in Medical Acupuncture for over 30 years.