Effect of acupuncture on the prevention of nausea and vomiting after laparoscopic cholecystectomy: a randomized clinical trial

Miranda et al. · Revista Brasileira de Anestesiologia · 2020

🔬Double-Blind RCT👥n=68 participantsHigh Clinical Impact

Evidence Level

MODERATE
75/ 100
Quality
4/5
Sample
3/5
Replication
3/5
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OBJECTIVE

To evaluate the efficacy of auricular acupuncture in the prevention of nausea and vomiting after laparoscopic cholecystectomy

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WHO

68 adult women (18-70 years) undergoing uncomplicated laparoscopic cholecystectomy

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DURATION

Needling for 20 minutes before anesthesia, 6-hour postoperative follow-up

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POINTS

Shen Men, Kidney, Sympathetic, Stomach, and Occipital (all auricular)

🔬 Study Design

68participants
randomization

Auricular Acupuncture

n=35

Auricular needles for 20 min + metoclopramide

Control

n=33

Metoclopramide only + placebo adhesives

⏱️ Duration: 6 postoperative hours

📊 Results in numbers

46% vs 82%

Reduction of nausea over total period

11% vs 45%

Reduction of vomiting over total period

p=0.03

Nausea at 2h postoperative

p=0.02

Vomiting at 6h postoperative

Percentage highlights

46% vs 82%
Reduction of nausea over total period
11% vs 45%
Reduction of vomiting over total period

📊 Outcome Comparison

Incidence of nausea (total period)

Auricular Acupuncture
46
Control
82

Incidence of vomiting (total period)

Auricular Acupuncture
11
Control
45
💬 What does this mean for you?

This study showed that auricular acupuncture (acupuncture in the ear) can significantly reduce nausea and vomiting after gallbladder surgery. Patients who received the treatment experienced less discomfort during the first 6 hours after surgery, making it a potentially safe and effective option as a complementary therapy.

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Article summary

Plain-language narrative summary

Laparoscopic gallbladder removal surgery, known as laparoscopic cholecystectomy, is one of the most frequently performed surgical procedures in Brazil and around the world. Although it is considered a safe and minimally invasive surgery, one of the most common and unpleasant complications affecting patients in the postoperative period is nausea and vomiting. These symptoms can cause great discomfort, prolong hospital stay, increase treatment costs, and, in some cases, lead to more serious clinical complications such as dehydration and changes in serum chemistry. Traditionally, the management of these symptoms is carried out exclusively with medications, which are not always fully effective and may have unwanted side effects.

As a result, there is growing interest in complementary therapies that can help control these symptoms.

This Brazilian study aimed to investigate whether auricular acupuncture, a specific Traditional Chinese Medicine technique that uses needles applied to specific points in the ear, could help prevent nausea and vomiting after laparoscopic gallbladder surgery. The research was conducted at the Oswaldo Cruz University Hospital in Pernambuco between December 2016 and September 2017. The study involved 68 adult women, between 18 and 70 years of age, who underwent uncomplicated gallbladder removal surgery. Participants were randomly divided into two groups: one received auricular acupuncture treatment in addition to standard medical care, and the other received only conventional medical care.

To ensure the reliability of the results, neither the patients, nor the surgeons, nor the anesthesiologists knew which group was receiving acupuncture. In the auricular acupuncture group, very fine sterile needles were inserted at five specific points of the ear before the start of anesthesia, remaining in place for 20 minutes. The points chosen were based on Traditional Chinese Medicine and on previous studies that showed efficacy in controlling nausea and vomiting.

The study results demonstrated that auricular acupuncture was effective in significantly reducing both the incidence and intensity of nausea and vomiting in the postoperative period. Specifically, 46% of patients in the control group experienced nausea, while only 27% of those who received auricular acupuncture had this symptom. With regard to vomiting, the difference was even more striking: 45% of patients in the control group vomited, compared with only 11% of those treated with acupuncture. The benefits were most evident in the second and sixth postoperative hours, periods that are critical for the development of these symptoms.

The intensity of nausea, measured using a visual scale that allows the patient to indicate the degree of discomfort, was also significantly lower in the group that received auricular acupuncture. Importantly, no complications or adverse effects related to the use of acupuncture were observed in any of the patients.

From a clinical standpoint, these results suggest that auricular acupuncture may be a valuable and safe tool for improving patient comfort after gallbladder surgery. For health care professionals, the study offers scientific evidence that integrating complementary therapies with conventional medical protocols can result in better outcomes for patients. The technique is relatively simple to apply, has low cost, requires specific but not overly complex training, and can easily be incorporated into surgical routines. For patients, it represents an additional non-pharmacological option that can significantly reduce postoperative discomfort without additional risk.

It is important to emphasize that auricular acupuncture proved effective as a complementary therapy — that is, it was used in conjunction with conventional medications, not as a complete substitute for standard treatment.

The study has some limitations that should be considered when interpreting the results. Because it was conducted at a single hospital, with a specific team of surgeons and anesthesiologists, the results may not be fully generalizable to other medical centers. Additionally, the research included only women at low risk for developing nausea and vomiting, excluding more complex cases or prolonged surgeries. The sample size, although adequate to demonstrate statistical differences, was relatively small, and the observation period was limited to the first six postoperative hours.

Future studies involving multiple medical centers, more diverse populations including men and more complex cases, longer observation periods, and larger samples could further strengthen the evidence on the effectiveness of auricular acupuncture. Despite these limitations, this research represents an important contribution to the Brazilian medical literature, offering rigorous scientific evidence on a safe and potentially effective complementary therapy for a common and clinically relevant problem in surgical practice.

Strengths

  • 1Randomized, double-blind, controlled study
  • 2Well-structured methodology following CONSORT guidelines
  • 3Statistically significant results
  • 4Absence of adverse effects from auricular acupuncture
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Limitations

  • 1Single-center study with relatively small sample
  • 2Included only women with few risk factors
  • 3Follow-up limited to 6 postoperative hours
  • 4Subjective assessment of nausea via visual scale
Prof. Dr. Hong Jin Pai

Expert Commentary

Prof. Dr. Hong Jin Pai

PhD in Sciences, University of São Paulo

Clinical Relevance

Postoperative nausea and vomiting (PONV) represent one of the most prevalent challenges in modern anesthesiology, directly affecting recovery, patient comfort, and hospital costs — particularly in laparoscopic cholecystectomies, where inhalational anesthesia, pneumoperitoneum, and opioids combine to substantially raise risk. This randomized double-blind trial conducted at a Brazilian university center demonstrates that auriculotherapy applied before anesthetic induction, combined with metoclopramide, reduces nausea from 82% to 46% and vomiting from 45% to 11% in the first six hours — clinically meaningful magnitudes. For the anesthesiologist and the acupuncturist physician working in the perioperative setting, these data support incorporating auriculotherapy as a component of the multimodal PONV prophylaxis strategy, particularly in female patients with a history of motion sickness or previous PONV, a risk profile widely recognized in the Apfel scales.

Notable Findings

The most notable finding is not just the absolute reduction of the outcomes, but the difference in magnitude between nausea and vomiting: while the reduction in nausea was relevant, the reduction in vomiting was even more pronounced — from 45% to 11% in the treated group. This suggests that auriculotherapy acts more effectively on the emetic reflex itself than on the nauseating sensation, which has interesting pathophysiological implications, possibly related to vagal modulation mediated by the selected auricular points. Statistical significance verified within the first two hours (p=0.03 for nausea) indicates that the action sets in early, coinciding with the period of greatest post-anesthetic vulnerability. The complete absence of adverse effects related to the technique reinforces the safety profile of auriculotherapy as a pharmacological adjuvant in controlled surgical environments.

From My Experience

In my perioperative practice at the Pain Center of HC-FMUSP, I have applied auriculotherapy in patients at high risk of PONV for more than a decade, and the pattern I observe is quite consistent with what Miranda et al. describe. I usually note a response already in the post-anesthesia recovery room, and the patient profile that responds best is exactly the one with a high Apfel score — female, non-smoker, with a history of motion sickness. The combination with ondansetron, which I prefer over metoclopramide in our service due to the lower incidence of extrapyramidal effects, appears to potentiate the antiemetic effect synergistically. I systematically use the Stomach, Shen Men, and auricular point zero points, a protocol close to the one adopted in this trial. For one-time prophylaxis in elective surgery, a single pre-induction session is sufficient; there is no need to schedule subsequent sessions for this specific objective, which greatly simplifies the logistics of integration into the surgical workflow.

Specialist physician in Medical Acupuncture. Adjunct Professor at the Institute of Orthopedics, HC-FMUSP. Coordinator of the Acupuncture Group at the HC-FMUSP Pain Center.

Full original article

Read the full scientific study

Revista Brasileira de Anestesiologia · 2020

DOI: 10.1016/j.bjane.2019.08.001

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Scientific Review

Marcus Yu Bin Pai, MD, PhD

Marcus Yu Bin Pai, MD, PhD

CRM-SP: 158074 | RQE: 65523 · 65524 · 655241

PhD in Health Sciences, University of São Paulo. Board-certified in Pain Medicine, Physical Medicine and Rehabilitation, and Medical Acupuncture. Scientific review and curation of every entry in this library.

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Medical disclaimer: This content is for educational purposes only and does not replace consultation, diagnosis, or treatment by a qualified professional. Some information may be assisted by artificial intelligence and is subject to inaccuracies. Always consult a physician.

Content reviewed by the medical team at CEIMEC — Integrated Centre for Chinese Medicine Studies, a reference in Medical Acupuncture for over 30 years.