Acupuncture and the retrospect of its modern research
Chen et al. · Romanian Journal of Morphology & Embryology · 2019
Evidence Level
MODERATEOBJECTIVE
To review the history of acupuncture and examine modern research on meridians and acupuncture points
WHO
Historical and scientific review — did not involve specific participants
PERIOD
Historical analysis from ancient times to contemporary research
POINTS
Zusanli, Neiguan, Sanyinjiao and a system of 365 main points
🔬 Study Design
Historical Review
n=0
Analysis of the evolution of acupuncture
Modern Research
n=0
Examination of current scientific studies
📊 Results in numbers
Acupuncture points mapped
Regular meridians identified
Extra meridians
Points adjacent to blood vessels
Percentage highlights
📊 Outcome Comparison
Types of Meridian Systems
This study reviews the rich history of acupuncture and examines the modern scientific research that helps explain how it works. The research shows that acupuncture points have specific anatomical features, including particular concentrations of blood vessels and nerves, providing a scientific basis for this centuries-old practice.
Article summary
Plain-language narrative summary
Acupuncture represents one of the oldest medical practices in traditional Chinese medicine, developed thousands of years ago when early peoples discovered that pain in one part of the body could be relieved through stimulation of other specific regions. This simple discovery evolved into a complex and sophisticated medical system that today is gaining worldwide scientific recognition. Interest in acupuncture has grown considerably due to its therapeutic efficacy, fewer side effects, low cost, and overall safety, especially in comparison with conventional treatments for various health conditions.
The article in question presents a comprehensive review that examines both the traditional foundations and the modern research on acupuncture, with particular focus on the system of meridians and acupuncture points. The researchers used a narrative review methodology, analyzing both classical texts of traditional Chinese medicine and contemporary scientific studies. The approach combines centuries-old historical knowledge with modern anatomical, physiological, and neurological investigations, seeking to understand the mechanisms by which acupuncture produces its therapeutic effects. The study examines everything from the first descriptions of meridians to recent research on the anatomical and functional bases of acupuncture points.
The main findings reveal that the meridian system constitutes a complex network of 14 main channels, including 12 regular meridians and two special meridians (Du and Ren), which are connected through smaller collaterals forming an intricate network throughout the body. Modern anatomical research has identified that acupuncture points have specific structural features, including a higher concentration of fine blood vessels, autonomic nerve plexuses, and lymphatic vessels. Electrophysiological studies have shown that these regions have distinct electrical properties, with higher conductivity and different electrical potentials. Neurological investigations confirmed that acupuncture significantly affects important neuro-hormonal systems, including the hypothalamic-pituitary-adrenal axis, the sympathetic nervous system and adrenal medulla, in addition to the thyroid and reproductive systems.
The research also revealed that the meridians have anatomical correspondences with specific neural segments, suggesting a neurological basis for the therapeutic effects observed.
For patients, these results provide a solid scientific basis explaining why acupuncture works for various health conditions. The finding that acupuncture points have specific anatomical structures and distinct electrical properties helps legitimize this centuries-old practice within Western medicine. For health professionals, the study provides evidence that acupuncture operates through well-defined neurological and neuro-hormonal mechanisms, not merely a placebo effect. The identification of the correspondence between meridians and neural segments offers a rational explanation for point selection and treatment strategies.
These findings suggest that integrative medicine, combining Eastern and Western approaches, may offer more effective treatments, especially for metabolic imbalances and chronic conditions where conventional medicine has limitations.
The study presents some important limitations that should be considered. The review is based primarily on existing literature, not presenting original experimental data that could strengthen the conclusions. Many of the cited studies are relatively old, and it would be beneficial to include more recent research using advanced imaging and molecular analysis technologies. The heterogeneity of the research methods cited makes it difficult to establish definitive conclusions about the exact mechanisms of acupuncture.
In addition, some aspects of traditional Chinese theory still lack clear correlation with modern scientific knowledge. Despite these limitations, the study represents a valuable effort to bridge traditional knowledge and modern science, offering a solid basis for future investigations. The evidence that acupuncture points have specific structural and functional features provides important direction for future research that can use more advanced technologies to fully elucidate the mechanisms of this ancient healing art.
Strengths
- 1Comprehensive review covering history and modern science
- 2Integration between traditional Chinese knowledge and Western research
- 3Detailed analysis of the anatomy of acupuncture points
- 4Scientific grounding of traditional concepts
Limitations
- 1Review article without new experimental data
- 2Some theories still require further scientific validation
- 3Limitations in fully understanding the mechanisms
- 4Need for additional controlled studies
Expert Commentary
Prof. Dr. Hong Jin Pai
PhD in Sciences, University of São Paulo
▸ Clinical Relevance
For those who practice acupuncture in a university hospital setting, having a synthesis that brings together classical foundations and contemporary neuroanatomical evidence is of direct pedagogical and clinical value. Confirmation that 84.79% of acupuncture points are located in regions of high vascular density and autonomic nerve plexuses provides concrete anatomical support for point selection in established protocols — particularly in the management of chronic conditions where neuro-hormonal modulation is central, such as pain syndromes, hypothalamic-pituitary-adrenal axis imbalances, and autonomic dysfunctions. The correspondence between meridians and specific neural segments, systematized in this review, reinforces the rationale of the segmental approach that many of us already use in practice, bringing the language of acupuncture closer to clinical neurology and facilitating dialogue with colleagues from other specialties.
▸ Notable Findings
The most striking structural finding of this review is that 84.79% of classical points are situated in proximity to fine blood vessels, autonomic plexuses, and lymphatic vessels — providing anatomical substrate for the idea that acupuncture stimulation is not random, but acts on zones of high neurovascular activity. Equally relevant is the electrophysiological evidence of higher electrical conductivity in these regions, functionally differentiating them from adjacent tissue. The neurological systematization of the 12 regular meridians and 8 extra meridians in correspondence with specific neural segments suggests that the traditional Chinese map can be reinterpreted as a functional chart of the somatic and autonomic nervous system, which opens a renewed perspective for understanding the therapeutic effects on the thyroid, reproductive, and hypothalamic-pituitary-adrenal neuro-hormonal axes.
▸ From My Experience
In my practice at the Pain Center of HC-FMUSP, this type of integrative review serves as essential reference material both for residents and for colleagues who come to acupuncture after conventional training and need a solid conceptual bridge. I have observed that physicians with neurophysiology training adhere much more quickly to the rationale of point selection when they understand the neuroanatomical basis of the meridians — and this article fulfills precisely that role of translation. From a practical standpoint, the evidence of modulation of the hypothalamic-pituitary-adrenal axis corroborates what I usually observe in patients with fibromyalgia and diffuse chronic pain: systemic responses that go beyond the local effect, perceptible as early as the first three to four sessions, with consolidation usually between the eighth and twelfth sessions. The profile that responds best, in my experience, is the patient with predominant autonomic involvement and low tolerance to conventional analgesics.
Indexed scientific article
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Scientific Review

Marcus Yu Bin Pai, MD, PhD
CRM-SP: 158074 | RQE: 65523 · 65524 · 655241
PhD in Health Sciences, University of São Paulo. Board-certified in Pain Medicine, Physical Medicine and Rehabilitation, and Medical Acupuncture. Scientific review and curation of every entry in this library.
Learn more about the author →Medical disclaimer: This content is for educational purposes only and does not replace consultation, diagnosis, or treatment by a qualified professional. Some information may be assisted by artificial intelligence and is subject to inaccuracies. Always consult a physician.
Content reviewed by the medical team at CEIMEC — Integrated Centre for Chinese Medicine Studies, a reference in Medical Acupuncture for over 30 years.
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